Answer:
The correct answer is: loss of diferenciation
Explanation:
The first signals of carcinoma are those which indicate cells are changing and loosing their function. Poorly differenciated cells in a tissue are those that lack of normal features the cell must posess to perform its specific function. They usually show altered shape and size, a larger size of nucleus- even a fragmented nucleus- and the tissue look more disorganized. These kind of cells have a higher rate of division and could potencially cause cancer.
